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These original compounds, such as miconazole and econazole, and those that followed, such as ketoconazole, fluconazole, and itraconazole, proved to be important drugs for combating human fungal infections.

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The disease is chronic, recurrent, and requires lifelong management.

Terbinafine must usually be taken for at least three or four weeks before any results are seen.

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Plasma levels of terbinafine and itraconazole fall rapidly after the end of treatment, and the shorter treatment requirements with both drugs further minimize the likelihood of systemic side effects ().

Intermittent pulse dosing with itraconazole is as safe and effective as short-term continuous therapy but more economical and convenient.

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